Congenic mice genetically identical except for one single locus

Identical Except For One Single Locus

Question:

Two strains of mice which are genetically identical except for a single genetic locus or region are said to be:

  1. Syngenic
  2. Allogenic
  3. Congenic
  4. Heterogenic

Rephrasing the question:

What is the term used for mice that are genetically identical except for one single locus?

Answer:

Congenic (option 3)

Explanation:

Let’s go through the options one by one.

  1. Syngenic: genetically identical, or sufficiently identical and immunologically compatible as to allow for transplantation. A syngeneic graft is also known as an isograft.

  2. Allogenic: genetically different because of being derived from separate individuals of the same species.

  3. Congenic: two strains/species that differ in only one locus and a linked segment of chromosome.

  4. Heterogenic: genetically different because of being derived from individuals of a different species
identical except for one single locus

Sources:

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